Bioinformatics research is focused on genome annotation, protein function prediction and study of gene regulatory networks in prokaryots. The Laboratory co-operate with other research groups at the Institute and in Slovakia, where bioinformatics approaches are applied. At the present time the main object of study are bacteriophages and characterisation and identification of transcription regulation systems of these primitive organisms. The phiSITE database is developed here, which collects and presents available data about phage genomes, genes, taxonomy, hosts bacteria and regulation of gene expression, using the web based application. Another project we are working on at the moment is phiBIOTICS - a database of bacteriophage enzybiotics. The Laboratory maintains the Slovak National EMBnet node.